Coursecode: wb2408
Coursename: Physiological Systems
DUT creditpoints: 2
ECTS creditpoints: 3 |
Faculty
of Mechanical Engineering and Marine Technology |
Lecturer(s):
Dankelman, dr. J., Grimbergen, prof.dr.ir. C.A. |
Tel.: 015-2785565 |
Catalog data:
Functioning of physiological systems described from an engineering point of view. Subjects
are heart, circulation, muscles, lungs, kidneys and nerve system. Modelling, measurement
techniques, design of artifical organs. |
Courseyear:
3, 4
Semester: 2/2/0/0/0
Hours p/w: 2
Other hours: -
Assessment: Oral
Assessm.period(s): Any time
(see academic calendar) |
Prerequisites:
- |
Follow
up: - |
Detailed
description of topics:
Introduction,
human body, homeostasis, general organization of the circulatory system.
Mechanics
of the heart muscle (contraction mechanism of cardiac muscle, action potentials).
Excitation
of the heart (electro cardiogram (ECG), transmission of pulses, pacemaker, body surface
mapping).
Cardiac
output, Frank-Starling mechanism (regulation of cardiac output, venous return, atrial
pressure, pulmonary resistance).
Wave
phenomena in the circulation (bloodflow, blood pressure, vascular compliance). Blood
rheology (blood cells, clotting, bloodflow in small vessels, Newtonian flow).
Coronary
circulation (control of coronary blood flow, influence of heart contraction on coronary
bloodflow, effect of stenoses).
Arterial
pressure regulation (control system, baroreceptors, influence of nerve system, control by
renal system).
Mass
transport ( diffusion, convection, osmosis, transport through cell membranes).
Lungs
(respiration, alveoli, transport of oxygen by red blood cells, transport of carbondioxide,
artificial lung).
Kidneys
(anatomy, glomerular filtration, reabsorption, regulation of blood volume, design of
artifical kidneys).
Central
nerve system (nerve cells, synapses, sensory system, motor system, autonomic nerve system,
reflexes).
Modelling
of physiological control systems (identification, difficulties).
Measurement
techniques, imaging techniques (invasive, noninvasive, catheters, ultrsound, echo,
Doppler, Röntgen, MRI).
Excursion
to the Academic Medical Center.
|
Course
material:
J. Dankelman, C.A. Grimbergen, J.A.E. Spaan.
Fysiologische Systemen (Physiological Systems) lecture notes in Dutch. |
References
from literature:
A.C. Guyton. Textbook of Medical Physiology. W.B.
Saunders Company. |
Remarks
(specific information about assesment, entry requirements, etc.):
An excursion to the academic Medical Centre in
Amsterdam will be organized. |
Goals:
This course is designed to provide students insight
in the working of several physiological systems such as heart, circulation, lungs, kidneys
and nerve system. The function of these systems will be described from an engineering
point of view. The student will learn about modelling techniques, measurement techniques,
design of artifical organs. |
Computer
use: |
Laboratory
project(s): |
Design
content:
The design of several artifical organs will be
discussed (e.g. artificial heart, valves, lung, kidney). |
Percentage
of design: 10% |