Coursecode: wb2408
Coursename: Physiological Systems

DUT creditpoints: 2
ECTS creditpoints: 3

Faculty of Mechanical Engineering and Marine Technology

Lecturer(s): Dankelman, prof. dr. J., Grimbergen, prof.dr.ir. C.A.

Tel.: 015-27 85565

Catalog data:
Functioning of physiological systems described from an engineering point of view. Subjects are heart, circulation, muscles, lungs, kidneys and nerve system. Modelling, measurement techniques, design of artifical organs.

Course year: MSc 1st year
Semester: 1B
Hours p/w: 4
Other hours: -
Assessment: Oral
Assessm.period(s): Any time
(see academic calendar)

Prerequisites: -

Follow up: -

• Introduction, human body, homeostasis, general organization of the circulatory system.

• Mechanics of the heart muscle (contraction mechanism of cardiac muscle, action potentials).

• Excitation of the heart (electro cardiogram (ECG), transmission of pulses, pacemaker, body surface mapping).

• Cardiac output, Frank-Starling mechanism (regulation of cardiac output, venous return, atrial pressure, pulmonary resistance).

• Wave phenomena in the circulation (bloodflow, blood pressure, vascular compliance). Blood rheology (blood cells, clotting, bloodflow in small vessels, Newtonian flow).

• Coronary circulation (control of coronary blood flow, influence of heart contraction on coronary bloodflow, effect of stenoses).

• Arterial pressure regulation (control system, baroreceptors, influence of nerve system, control by renal system).

• Mass transport ( diffusion, convection, osmosis, transport through cell membranes).

• Lungs (respiration, alveoli, transport of oxygen by red blood cells, transport of carbondioxide, artificial lung).

• Kidneys (anatomy, glomerular filtration, reabsorption, regulation of blood volume, design of artifical kidneys).

• Central nerve system (nerve cells, synapses, sensory system, motor system, autonomic nerve system, reflexes).

• Modelling of physiological control systems (identification, difficulties).

• Measurement techniques, imaging techniques (invasive, noninvasive, catheters, ultrsound, echo, Doppler, Röntgen, MRI).

• Excursion to the Academic Medical Center.

Course material:
J. Dankelman, C.A. Grimbergen, J.A.E. Spaan. Fysiologische Systemen (Physiological Systems) lecture notes in Dutch.

References from literature:
A.C. Guyton. Textbook of Medical Physiology. W.B. Saunders Company.

Remarks (specific information about assesment, entry requirements, etc.):
An excursion to the academic Medical Centre in Amsterdam will be organized.

Goals:
This course is designed to provide students insight in the working of several physiological systems such as heart, circulation, lungs, kidneys and nerve system. The function of these systems will be described from an engineering point of view. The student will learn about modelling techniques, measurement techniques, design of artifical organs.

Computer use:

Laboratory project(s):

Design content:
The design of several artifical organs will be discussed (e.g. artificial heart, valves, lung, kidney).

Percentage of design: 10%