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Coursecode: wb2408
Coursename: Physiological
Systems
ECTS creditpoints: 3 |
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Faculty
of Mechanical Engineering and
Marine Technology |
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Lecturer(s): Dankelman, prof. dr. J., Grimbergen, prof.dr.ir.
C.A. |
Tel.:
015-27
85565 |
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Catalog data:
Functioning of
physiological systems described from an engineering point of view.
Subjects are heart, circulation, muscles, lungs, kidneys and nerve system.
Modelling, measurement techniques, design of
artifical organs. |
Course year:
MSc 1st year
Course
language:
English
Semester:
1B
Hours p/w: 4
Other hours: -
Assessment:
Oral
Assessm.period(s): Any
time
(see academic calendar) |
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Prerequisites: - |
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Follow
up:
- |
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Detailed
description of topics:
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Introduction, human body,
homeostasis, general organization of the circulatory system.
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Mechanics of the heart
muscle (contraction mechanism of cardiac muscle, action
potentials).
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Excitation of the heart
(electro cardiogram (ECG), transmission of pulses, pacemaker, body
surface mapping).
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Cardiac output,
Frank-Starling mechanism (regulation of cardiac output, venous return,
atrial pressure, pulmonary
resistance).
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Wave phenomena in the
circulation (bloodflow, blood pressure,
vascular compliance). Blood rheology (blood
cells, clotting, bloodflow in small vessels,
Newtonian flow).
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Coronary circulation
(control of coronary blood flow, influence of heart contraction on
coronary bloodflow, effect of stenoses).
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Arterial pressure regulation
(control system, baroreceptors, influence of
nerve system, control by renal system).
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Mass transport ( diffusion, convection, osmosis, transport through
cell membranes).
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Lungs (respiration, alveoli,
transport of oxygen by red blood cells, transport of carbondioxide, artificial lung).
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Kidneys (anatomy, glomerular filtration, reabsorption, regulation of blood volume, design of
artifical kidneys).
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Central nerve system (nerve
cells, synapses, sensory system, motor system, autonomic nerve system,
reflexes).
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Modelling of physiological control
systems (identification, difficulties).
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Measurement techniques,
imaging techniques (invasive, noninvasive, catheters, ultrsound, echo, Doppler, Röntgen, MRI).
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Course
material:
J. Dankelman, C.A.
Grimbergen, J.A.E. Spaan. Fysiologische Systemen
(Physiological Systems) lecture notes in Dutch and in English (under
preparation). |
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References from
literature:
A.C. Guyton. Textbook of
Medical Physiology. W.B. Saunders Company. |
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Remarks (specific
information about assesment, entry requirements,
etc.):. |
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Goals:
This course is designed to
provide students insight in the working of several physiological systems
such as heart, circulation, lungs, kidneys and nerve system. The function
of these systems will be described from an engineering point of view. The
student will learn about modelling techniques,
measurement techniques, design of artifical organs. |
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Computer
use: |
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Laboratory
project(s): |
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Design
content:
The design of several
artifical organs will be discussed (e.g.
artificial heart, valves, lung, kidney). |
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Percentage of
design:
10% |