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Coursecode: wb2408
Coursename: Physiological
Systems
ECTS creditpoints: 3 |
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Faculty
of
Mechanical Engineering and
Marine Technology |
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Lecturer(s): Dankelman, prof. dr. J., Grimbergen, prof.dr.ir.
C.A. |
Tel.:
015-27
85565 |
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Catalog data:
Functioning of
physiological systems described from an engineering point of view.
Subjects are heart, circulation, muscles, lungs, kidneys and nerve system.
Modelling, measurement techniques, design of
artifical organs. |
Course year:
MSc 1st year
Course
language:
English
Semester:
1B
Hours p/w: 4
Other hours: -
Assessment:
Oral
Assessm.period(s): Any
time
(see academic calendar) |
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Prerequisites: - |
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Follow
up:
- |
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Detailed
description of topics:
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Introduction, human body,
homeostasis, general organization of the circulatory system.
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Mechanics of the heart
muscle (contraction mechanism of cardiac muscle, action
potentials).
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Excitation of the heart
(electro cardiogram (ECG), transmission of pulses, pacemaker, body
surface mapping).
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Cardiac output,
Frank-Starling mechanism (regulation of cardiac output, venous return,
atrial pressure, pulmonary
resistance).
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Wave phenomena in the
circulation (bloodflow, blood pressure,
vascular compliance). Blood rheology (blood
cells, clotting, bloodflow in small vessels,
Newtonian flow).
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Coronary circulation
(control of coronary blood flow, influence of heart contraction on
coronary bloodflow, effect of stenoses).
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Arterial pressure regulation
(control system, baroreceptors, influence of
nerve system, control by renal system).
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Mass transport ( diffusion, convection, osmosis, transport through
cell membranes).
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Lungs (respiration, alveoli,
transport of oxygen by red blood cells, transport of carbondioxide, artificial lung).
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Kidneys (anatomy, glomerular filtration, reabsorption, regulation of blood volume, design of
artifical kidneys).
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Central nerve system (nerve
cells, synapses, sensory system, motor system, autonomic nerve system,
reflexes).
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Modelling of physiological control
systems (identification, difficulties).
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Measurement techniques,
imaging techniques (invasive, noninvasive, catheters, ultrsound, echo, Doppler, Röntgen, MRI).
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Course
material:
J. Dankelman, C.A.
Grimbergen, J.A.E. Spaan. Fysiologische Systemen
(Physiological Systems) lecture notes in Dutch and in English (under
preparation). |
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References from
literature:
A.C. Guyton. Textbook of
Medical Physiology. W.B. Saunders Company. |
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Remarks (specific
information about assesment, entry requirements,
etc.):. |
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Goals:
The student must be able to:
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describe the function of heart, circulation, heart muscle, lungs, kidney
and nerve system
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illustrate heart muscle mechanics (contraction mechanism, action
potentials)
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reproduce the electrical activity in the heart (ECG, pacemaker, body
surface mapping)
sum up variables determining cardiac output (Frank-Startling mechanism,
venous return, pulmonary resistance)
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describe wave and rheological phenomena in the circulation (blood flow
and pressure, vascular compliance, blood cells, blood clotting, blood
flow in small vessels, Newtonian flow)
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sum up mechanisms for arterial pressure regulation (control system,
baroreceptors, influence of nerve system, control by neural system)
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identify transport mechanisms in the human body (diffusion, convection ,
osmosis, transport through cell membranes, active transport)
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explain different imaging techniques (ultrasound, Rontgen, MRI)
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reproduce design criteria for artificial organs (heart (valves), lungs,
kidney)
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formulate the problems of applying standard modeling and identification
techniques
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Computer
use: |
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Laboratory
project(s): |
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Design
content:
The design of several
artifical organs will be discussed (e.g.
artificial heart, valves, lung, kidney). |
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Percentage of
design:
10% |